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Inflammatory bowel disease is a result of immunologic imbalances at the interface of the intestinal lumen (the hollow part of the digestive tract through which food passes) and the intestinal epithelium (the inward-facing surface of the intestinal wall)

In summary, therapeutic strategies targeting CTGF, such as siRNA and microRNA-based approaches, show promise in improving glaucoma management

Future studies should adopt quantitative and standardized methods, such as transmission electron microscopy with immunogold labeling, 221 subcellular fractionation combined with mass spectrometry, 222 and super-resolution imaging in tissue sections, 223 to allow more reliable and comparable evaluation

To determine whether GSH depletion can also exert protective effects in a primarily MASH model, we overexpressed Chac1 in mouse liver using AAV8 followed by challenging mice with methionine/choline-deficient diets (MCDs) to induce MASH