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Comprehensive cancer pre-screening represents a crucial component of patient evaluation due to the potential for these peptides to stimulate angiogenesis, which could theoretically promote malignant growth and metastasis

Inhibition of P4H leads to HIF-1 activation under normoxic conditions, resulting in pseudohypoxia that promotes the proliferation of cancer cells (79)

It is worth noting that the ROS production and the percentage of apoptotic and dead cells are significantly higher in leiomyoma cells