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When followed by ATO, the resulting ROS accumulation exceeds the threshold for cell death, even in non-APL leukemia cells that are otherwise resistant to ATO alone [314]

The Hylemon-Bjrkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology

The intracellular phosphate concentration is significantly higher than the extracellular, and this concentration gradient leads to cGAMP/MOL release of cGAMP (Fig