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This multisystem disorder has diverse manifestations including neurocognitive, skeletal and cardiovascular abnormalities, and is also classified as a neurocutaneous syndrome to highlight its manifestations primarily in the nervous system and the skin as a result of lesions affecting neural-crest-derived tissues such as Schwann cells and melanocytes

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Another open-label, randomized, controlled trial evaluated the effect of citicoline (1,000 mg/day for 12 months) in 347 subjects (mean age, 67.2 years) who suffered an acute stroke