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IgA is the antibody isotype most present in the mucosal immune system and consists of its main defense mechanism

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In view of the structure and composition, the constructed siRNA delivery nanosystem is called siRNA-encapsulated and aptamer-incorporated core/shell (CS) nanoparticle (siRNA/Ap-CS) that exhibits high serum stability, tumor-specific targeting ability, long circulation lifetime and controlled siRNA release in endogenous miRNA-responsive fashion