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Several standard modes of action include receptor-mediated targeting (Lohiya and Katti, 2022), intrinsic drug distribution (Yee Kuen and Masarudin, 2022), cellular uptake and delivery (Baghani et al., 2022), pH-responsive pharmacological discharge (Dongsar et al., 2023), optimized drug accumulation and retention (Herdiana et al., 2023), focused immune system modulation (Karimi K

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322,323 CryAB also associates with tau fibrils and shows an inverse correlation with granular tau species, suggesting a protective role in limiting tau aggregation and toxicity in tauopathies