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Furthermore, considering the significant role that mitochondrial function and biogenesis play in long-term aerobic adaptation and exercise performance and the involvement of NO in these pathways, our understanding of NO and the application of nitrate supplementation would greatly benefit from continued investigation within these topics

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Further, the inherent limitations of studying topical dosing in murine models necessitates further studies of pharmacokinetics and efficacy in larger species, as well as ocular safety and tolerability studies

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