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515MO Phase Ib study of telisotuzumab vedotin (Teliso-V) and osimertinib in patients (Pts) with advanced EGFR-mutated (Mut), c-Met overexpressing (OE) non-small cell lung cancer (NSCLC): final efficacy and safety updates

Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety