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Rttig A, Wenning L, Brker D, Steinbchel A

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At relatively high concentrations, lactate enhances histone H3 lysine 27 acetylation (H3K27ac) at Tcf7 superenhancer sites by inhibiting histone deacetylase activity, thereby increasing Tcf7 gene expression in CD8 + T cells to increase their stemness and improve the efficacy of anti-PD-1 therapy