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For the surgery, mice were anesthetized with 5% isoflurane in oxygen (1 L/min), and after confirmation of anesthesia by the absence of voluntary movement, the abdominal area was sanitized with betadine and 70% isopropyl alcohol (3 alternating scrubs), covered with a sterile drape prior to surgical incision to access the intraperitoneal cavity, and a sterilized thermoprobe was tied securely to the back skin with a 7 0 silk suture

The SURMOUNT program is composed of multicenter double-blind RCT evaluating the efficacy and safety of OW tirzepatide compared to placebo on top of dietary and physical activity recommendations in patients with obesity or BMI 27 kg/m 2 with 1 weight-related complication 9

Bandeira, S., Gonzalez-Garcia, J., Pensa, E., Albrecht, T