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As of recent discovery IGF-2R shows to activate G q proteins within cardiomyocites [104]

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Due to the clinical resemblance with cEDS, recent updated nosology has renamed the condition classical-like EDS (clEDS)

Studies, primarily in animal models, have explored its effects on a sprawling range of tissues: muscle tears, transected ligaments, tendon-to-bone healing, nerve damage, and more