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This dynamic interplay must be taken into consideration when targeting invasion in GBM

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Saltiel, A

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So far, it appears that their role depends on the H 2 O 2 levels within RBC: CAT is crucial for scavenging high exogenous and endogenous peroxide levels, GPx and Prx2 are important for scavenging low endogenous and low peroxide levels

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However, intracellular GSH at high concentrations inactivates ROS and reduces efficacy

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