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Some key biological causes include: Neurochemical Changes: Nicotine, the primary psychoactive component of tobacco, interacts with nicotinic acetylcholine receptors in the brain, leading to the release of neurotransmitters such as dopamine, as discussed by Berrendero, F

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Although both groups had similar frequencies of chronic obstructive pulmonary disease (COPD) exacerbations worsening of the condition throughout the study, menthol smokers had a higher frequency of severe exacerbations at 0.22 per year, compared to 0.18 per year for regular cigarette smokers

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