glutathione peroxidase enzyme mimetics New mimetics—Insights into antioxidant and cytotoxic activity Functional Mimics of Glutathione Peroxidase:

the yeast strain has a mutation that reduces the ability of the strain to synthesise one or more proteins, metabolites and/or essential growth factors which may optionally be included in the culture medium in limiting amounts, depending on the capacity of the yeast strain to synthesise said proteins, metabolites and/or essential growth factors

Crucially, we integrate the parallel and essential discourse on safety, highlighting how zebrafish models, especially transgenic lines, enable the real-time visualization and mechanistic interrogation of compound-induced hepatotoxicity

doi: 10.1016/S1470-2045(23)00444-8 35 LoMWangYZGoutPW

Tax1 binding protein 1 (TAX1BP1), functioning as an autophagic receptor for GPX4, facilitates this degradation, leading to enhanced lipid peroxidation and subsequent ferroptosis [57]