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Both (M+D)/2 and (M+D+V)/3 combinations increased superoxide production after 24 hours, as well as H 2 O 2 ( Figures 8A, B )

Resistance mechanisms, such as GPX4 upregulation, further complicate treatment

The same protective effect against Ca2 + overload was also observed in the brain mitochondria of rats, where lithium increased the activity of mitochondrial complexes I, II, and III [68]