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Ann Neurol 50:582587

Coincidentally, sulfhydrylases, including MetZ, use H 2 S as the S-donor in reactions that involve cysteine and homocysteine biosynthesis

Overexpression of CBS was found to inhibit phosphodiesterase 4A (PDE4A) and phosphodiesterase 8A (PDE8A) via persulfidation, implicating that it is possible that by inhibiting PDE expression via persulfidation and activating the cAMP/PKA pathway that regulates testosterone synthesis, which could be restored ( Figure 5 )