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Inotersen: first global approval

States JC, Srivastava S, Chen Y, Barchowsky A

Further research has shown that activated ErbB2 stimulates GLS expression in breast cancer cells through the PI3K/Akt-independent NF-B pathway (197)

Human COP1 plays a key role in the ubiquitination of a wide range of transcriptional regulators, including p53, c-Jun, and members of the ETS, and C/EBP families 20,25,26,27,28,29