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A combination of protein misfolding, mitochondrial dysfunction, oxidative stress, neuroinflammation, and iron-mediated toxicity converge to disrupt neuronal homeostasis (Behl et al., 2022

Together, these studies illustrate thrombins advantages in tag removalsuch as established specificity and compatibility with detergentsand its limitations, including potential promiscuous cleavage and residual N-terminal extra residues [151,152]

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