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However, it has serious disadvantages, for example, compromising the integrity of BBB and further leading unwanted exogenous agents, including blood components, neurotoxic, and xenobiotics, to accumulate in cerebral tissue

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Lack of FDA approval and standardized clinical data limits confirmed use in medical practice despite promising preclinical findings

Epigenetic modifications have been reported to induce a series of changes in gene expression and protein levels that result in mitochondrial abnormalities and neuronal apoptosis and lead to PD (Zhang et al., 2021), long non-coding RNAs ( Mitochondrial Quality Control in Parkinsons Disease Quality control mechanisms are essential to maintaining a healthy mitochondrial network and cell homeostasis, especially to dopaminergic neurons