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An example of this is macrodoses, also known as pharmacological doses, which can only be provided through supplements

[DOI] [PubMed] [Google Scholar] Rinaldi Garaci C., et al

ROS are reactive forms of oxygen which include superoxide anion radical, hydrogen peroxide, singlet oxygen and hydroxyl radical, they are usually produced during normal metabolism of oxygen inside the mitochondria [116]

In Studies JMDB and JMCH, among patients who received vitamin supplementation, incidence of Grade 3 to 4 neutropenia was 15% and 23%, the incidence of Grade 3 to 4 anemia was 6% and 4%, and incidence of Grade 3 to 4 thrombocytopenia was 4% and 5%, respectively