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Perrone et al., 2012)

DOI:10.1016/j.ajpath.2014.12.017 30

Activation of the upstream regulator peroxisome proliferator-activated receptor (PPAR) induces the expression of ferroptosis suppressor protein 1 while simultaneously downregulating APP synthesis and inhibiting -site APP cleaving enzyme 1 hydrolytic activity, effectively reducing A oligomer generation (121)