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Eric Topol, a research methods expert and director of Scripps Research Translational Institute, said in April during a call with reporters hosted by the Harvard T.H

In addition to T-brachyury, expression of Sonic hedgehog ( Shh ) and hepatocyte nuclear factor ( HNF )-3 (also known as FoxA2 ) is important for successful differentiation and survival of notochordal cells (Risbud and Shapiro, 2011)