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The central challenge for this fungal pretreatment, however, is economic: the process is often slower and less amenable to continuous industrial operation than established physicochemical methods (e.g., steam explosion, acid hydrolysis), raising concerns about capital costs and volumetric productivity at scale (Zhu et al., 2024)

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For those with the autoimmune-related pernicious anemia who have difficulty properly absorbing B12, injections are usually recommended in most countries, but again, oral has worked well if enough it used