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The effect of TZDs on insulin sensitivity is mediated by the activation of PPAR, a nuclear receptor that regulates the transcriptions of several genes involved in glucose and lipid metabolism and energy balance and increases fat oxidation, adipocyte proliferation, lipogenesis, fat redistribution, and reduces plasma free fatty acid and pro-inflammatory cytokine levels [159]

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Chronic pain is an ordinary complication after SCI, accounting for about 61% of all patients, while NP is considered the most severe pain post-SCI, with an estimated prevalence of 53% reported (88, 89)

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