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PKC1 expressed in the proximal tubule is critical for inducing the expression of transforming growth factor-1 (TGF1), which is an essential mediator of the switch from proliferation to hypertrophy in renal proximal tubular cells during the early stage of DKD through the extracellular signal-regulated kinase (ERK) and p38 pathway

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Existing reviews have further highlighted that pharmacokinetic and safety characterization in humans remains incomplete, complicating clinical counseling regarding timing of discontinuation, perioperative risk stratification, and postoperative resumption (Rahman et al

Activation of RAAS also leads to the release of aldosterone, a mineralocorticoid hormone, from the adrenal glands