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In clinical trial, the proportion of NAFLD patients treated with silybin combined with vitamin A and D shows a statistically significant improvement in metabolic markers, oxidative stress, endothelial dysfunction [97, 117]

A.XuC.et al

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The mechanism through which COCs exert their therapeutic effects involves the suppression of ovarian activity, reducing the estrogen-induced production of prostaglandins and therefore tissue inflammation [59]