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Children with ASD also have significant decreases in methionine levels and the ratio of plasma S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) (SAM: SAH ratio), an index of methylation capacity ( Most importantly, children with ASD also have decreased levels of total glutathione and the reduced or active form of glutathione ( Although prior nutritional interventions addressing antioxidant capacity have successfully improved glutathione levels, the association between these changes and autistic behavior has been less compelling

According to Du Plessis and his coworkers [17], both Ca 2+ ions and ROS are involved in the initiation of the capacitation to cause the activation of adenylate cyclase which results in the production of cyclic adenosine monophosphate (cAMP)

During the manuscript submission process, two other fluorescent probes were independently reported to monitor GSH dynamics in living cells 38,39