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Herein, we discuss: i) the dynamic role of TAMs in glioblastoma

The accumulation of ROS prevents Nrf2 from being ubiquitinated by modifying the cysteine in Keap1, allowing Nrf2 to be expressed stably in the nucleus and activating the antioxidant reaction elements (ARE), which include the expression of a series of antioxidant genes such as GSH, GCL, HMOX , and GSL (46)

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When performed by experienced surgeons in expert centers, discoid excision is considered safe, with postoperative complication rates of 24.5% (mostly minor Clavien-Dindo grades I-II) and no severe complications like rectovaginal fistula or anastomotic leakage reported (60)