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Low levels of copper disrupt brain amyloid-beta homeostasis by altering its production and clearance

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However, completely abolishing BACE1 by knocking out the BACE1 gene has adverse effects on recovery after SCI such as delayed myelination and decreased myelin thickness (hypomyelination) due to a dysregulation of neuregulin-1 type III, an EGF-like growth factor (Hu et al., 2006