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Discussion Though the efficacy of cuprizone pellets has been debated 27,28 , research has proven that at more chronic timepoints cuprizone pellets can induce reliable demyelination 29,30,31,32,33,34,35

In the group of children with Down syndrome this correlation was not found

T cells deficient in autophagy displayed reduced SAM level, which was associated with decreased global expression of H3K27me3, increased H3K4me3 density in the promotor regions of effector genes, and enhanced anti-tumor function of mouse CD8+ T cells ( via the regulation of histone methylation