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After confirming the feasibility of our proposed kinetic assay, we proceeded to integrate determination of NADPH in subcellular compartments using targeted Apollo-NADP + sensors

In addition to this, many people have problems metabolizing B12 in low-quality forms like cyanocobalamin due to defects in the MTHFR gene (1) (as many as 40% of people have THIS problem!)

Plant Physiol 186:497518 Veillet F, Perrot L, Chauvin L, Kermarrec M-P, Guyon-Debast A, Chauvin J-E, Nogu F, Mazier M (2019) Transgene-free genome editing in tomato and potato plants using agrobacterium-mediated delivery of a CRISPR/Cas9 cytidine base editor