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However, further studies are necessary to confirm these findings, clarify the extent of functional recovery, and elucidate the underlying mechanisms

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In addition to the anesthetic effect of cocaine by blocking sodium channels, the cocaine-induced cardiovascular disorders are mainly due to its potent sympathomimetic effect, which is achieved by the blockage of catecholamine reuptake at neuronal presynaptic terminals 9,10

Significant predictors of worsened curvature were the presence of diabetes and, in contrast to Berookhim (2014), younger age