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3.2 Chemical instability under physiological and processing conditions Curcumin is notably unstable in both physiological fluids and during standard processing conditions, undergoing rapid degradation that compromises its therapeutic efficacy and shelf stability

Similarly, the reduction in EGR1 and FOS suggests a potential mechanism for curbing death receptor signaling and activator protein-1 (AP-1)-mediated inflammation 67,68,69 , While the downregulation of MAP3K8 (TPL2) might modulate the balance between the TGF- -Activated Kinase 1 (TAK1)-NFB and ASK1-c-Jun N-terminal Kinase (JNK) pathways 70

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El-Maadawy WH, Hassan M, Hafiz E, Badawy MH, Eldahshan S, AbuSeada AR, El-Shazly MAM, Ghareeb MA (2022) Co-treatment with esculin and erythropoietin protects against renal ischemiareperfusion injury via P2X7 receptor inhibition and PI3K/Akt activation