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Induced regulatory T cells (iT reg ), differentiated from peripheral CD4 + T cells, are a unique subset of CD4 + T cells that suppress effector T cells and are vital to immune peripheral tolerance ( reg differentiation (e.g., IL-2 and TGF-) acquire a metabolic phenotype similar to nave T cells ( regs and their thymically derived nT reg counterparts have intermediate to low mTOR activity ( reg can be replicated through in vitro culture with addition of glycolytic or mTOR inhibitors, such as 2-deoxyglucose or rapamycin, respectively ( regs , serving as fatty acid sensors, and promoting Foxp3 expression in CD4 + T cells activated in the presence of TGF- ( Fatty acid oxidation also plays a vital role in the maintenance of memory T cell pools

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