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Targeted therapy resistance, a major clinical challenge, is amenable to intervention via the autophagy-ferroptosis axis, a key determinant of cell fate under stress, through two primary strategies

Studies should also be carried out on several patients to establish a therapeutic dose, mode of administration, optimal targets, and even the need to administer other antioxidants simultaneously with VIC [52]

doi: 10.1016/j.bbrc.2007.10.038 46 SunHYuanYSunZL

Funding This work was financially supported by the National Natural Science Foundation of China (82071434), the Natural Science Foundation of Jiangsu Province (BK20201490), Nanjing Medical University Specific Disease Cohort Study Project (JX218GSP20211804A), Jiangsu Province Six Talent Peak High-Level Talent Selection and Training Programme (WSN-004), the 511 Project, and Jiangsu Province Hospital (the First Affiliated Hospital with Nanjing Medical University) Clinical Capacity Enhancement Project