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The results showed that the body weight of the DON-treated group significantly decreased, while the weight of the DON + melatonin co-treatment group was closer to normal levels compared to the DON group (Supplementary Fig

Among the 11xenobiotic, the most significant positive and negative causal association with the onset of psoriasis was observed with elevated Umbelliferone sulfate levels (OR: 2.06, 95% CI: 1.53-2.79, P Wald Ratio =2.4910 -6 , P FDR =0.002) and elevated 4-vinylphenol sulfate levels (OR: 0.53, 95% CI: 0.28-0.97, P Wald Ratio = 0.041, P FDR = 0.538)

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Vitamin B6 (pyridoxine) is a group of six water-soluble compounds with a similar chemical structure, all of which can be converted into their active form of pyridoxal 5-phospate (PLP)