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For example, people with Type 1 diabetes might take metformin to reduce the amount of insulin needed since it helps improve insulin action in the body

It is essential for controlling vesicular transportation [132] and for protection against osmotic and mechanical stress [133]

The use of orthotopic or patient-derived xenograft (PDX) models in future in vivo studies will provide an opportunity to further evaluate biodistribution, long-term toxicity, immune responses, and tumor-bone interactions 111,112