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Toxicol Sci 137:12

Fentanyl-induced reward seeking is sex and dose dependent and is prevented by D-cysteine ethylester

Independently of this -MSH/MC1R pathway, PGE 2 can promote tyrosinase activity and arborisation of melanocytic dendrites

This may mediate activation of perivascular Ms, microglia, and astrocytes, and initiate further immune responses within the brain parenchyma, suggesting neuroinflammation can be triggered by signaling from the periphery, without primary injury or disease originating within the CNS