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Lun SC, Guo HD, Onajole OK, Pieroni M, Gunosewoyo H, Chen G, et al

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TAK-242 is a small-molecule inhibitor of TLR-4 that showed promising results in murine models of LPS-induced acute-on-chronic liver failure (ACLF) [45]

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The mechanisms that drive this association include systemic inflammation, endothelial dysfunction, oxidative stress, hypertension, and metabolic dysfunction

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The most promising approach is to enhance the bioavailability of bioactive compounds using new pharmaceutical nanoformulations (166)

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