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showed that isatuximab can preferentially block Tregs and enhance NK and CD8 + T-effector cell-mediated immune responses, effectively restoring immune effector functions against MM cells [31]

ORP5 regulates PA storage in lipid droplets independently of ORP8 and seipin To further investigate the role of ORP5 in PA metabolism, we monitored the incorporation of exogenous PA into LDs using TopFluor-TMR-PA under overexpression of different ORP5 constructs in fixed cells

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reported a faster intramolecular interchange reaction ( i.e., ring closure) step compared to the initial attack of the dithiol on the disulfide (in all studied cases even at very low reactant concentrations) (104)