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The next step of our study was to modulate macroscopic and histological outcomes testing the clinically active glucocorticoid prednisolone 43 and the mast cell stabiliser nedocromil

doi: 10.1212/WNL.0b013e318217e7dd 44 EveD

Therapeutic use of carbamylglutamate in the case of carbamoyl-phosphate synthetase deficiency

Enhancement of SAMe levels permit it to act as the cofactor of COMT, which prevents catalysis in the first step in a degradation pathway of the catecholamine neurotransmitters, and can therapeutically decrease COMT enzyme activity [183]