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High IGF-1 levels from hGH cause growth-promoting and metabolic effects

Doi:10.1152/japplphysiol.00945.2010 Seiwerth S, Brcic L, Vuletic LB, et al

This creates a dual burden where both disease prevalence and treatment gaps coexist, increasing long-term complications and reducing life expectancy in underserved regions [4][3]