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Hepatic lobules are primarily divided into three zones, with Zone 1 hepatocytes near portal vein (PV) areas and connecting points, Zone 3 hepatocytes around the central vein (CV), and Zone 2 hepatocytes positioned between them (Paris and Henderson, 2022)

Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway