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Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimers disease: role of lipid peroxidation in Alzheimers disease pathogenesis

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EF-hand domains Highly conserved Ca 2+ -binding domains comprising two helices (E and F after the 5 th and 6 th helices of parvalbumin) that are linked by a short acidic Ca 2+ -binding loop

In the case of LPA signaling, downstream effectors such as PI3K, MAPK, and Rho GTPase orchestrate critical cellular functions, including proliferation, migration, and survival, mirroring the layered architecture of neural networks that process inputs across multiple nodes to derive complex outputs