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This relationship provides further evidence that an autoimmune mechanism may be involved, given that the relationship between certain HLA-II alleles and autoimmune diseases is widely recognized (95)

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doi: 10.2174/138945012799201595

Although more RCTs are needed to draw convincing conclusions about efficacy in FM, antidepressants in monotherapy or in combination with a2d ligands are considered a valid treatment option for patients with FM