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Cell Biology Reports, 34(2), 111127

Further, in a mouse model of Alzheimer's disease, NMN was found to reduce the levels of amyloid precursor protein (APP), reverse the oxygen consumption deficit in brain mitochondria, and reduce mitochondrial fragmentation in neurons, thereby improving the mitochondrial respiratory defect [40]

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The C677T variant is associated with reduced enzyme activity, lower SAM levels, and increased HHcy, predisposing individuals to cognitive decline and psychiatric disorders