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Among these markers, Mmp12 and osteopontin ( Spp1 ) are essential for the development of smoke-induced emphysema in mice whereas MMP-12/SPP-1 levels in sputum were shown to correlate with the extent of emphysema in COPD patients ( hi /CCR2 + monocytes using adoptive transfer studies and monocytes from wild type and CCR2-deficient mice ( Ccr2 + CMo differentiates via a common CMo/macrophage intermediate state into MoAM besides differentiating into IM