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10.1016/j.mad.2009.05.001 Mech

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Nei modelli l'AHK-Cu aumentava l'espressione di VEGF, incrementava la proliferazione dei fibroblasti dermici e la densita capillare perifollicolare, suggerendo un migliore apporto vascolare ai follicoli

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In the cell culture model of Wilsons disease, excessive copper accumulation unleashed a cascade of cellular stress responses, including autophagy, oxidative stress, and inflammation driven in part by the dysregulation of key signalling hubs such as NFKB and AP1

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