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doi: 10.3390/antiox9080681, 93 HatamlehA

doi: 10.1002/jcb.v120.2 10 WadhwaSKKaziTGAfridiHITalpurFNNaeemullah

Notably, a propargyl group at P1 or alternatively an extended P1 side chain resulted both in very potent and fairly selective IRAP inhibitors, 45 (DG046) with IC50 values of 2 nM and 46 with a IC50 value of 4 nM (Figure 11)