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In contrast, strategies using growth hormone-releasing factor (GRF)/growth hormone-releasing hormone (GHRH) analogues to induce physiological increases of GH and preserve the insulin-like growth factor-1 (IGF-1) negative feedback have been shown to correct metabolic abnormalities and body composition changes associated with low GH levels with fewer side effects, particularly with regard to hyperglycemia [58]

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McPhee SJ, Papadakis MA, Rabow MW (2014) Current medical diagnosis & treatment

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